Retrospective analysis of chromosomal abnormalities was performed on 210 individuals who had recurrent spontaneous abortion. Karyotyping of their peripheral blood lymphocytes was made on 110 patients and 100 their husbands.
The overall incidence of translocations was 3.3 % (7/210). Number of translocations in wives were five; 45, XX, t(15:15), 45, XX, t(13:15), 46, XX, t(4;15),(7:17),46, XX, 5(9;17), 46, XX, t(6;7). Another translocation were found in 2 husbands; 46, XY, t(l 1:18), 46, XY, t(18;22). The origin of each translocations were classified as De novo in 3 patients, familial in one, and unknown in 3 cases. The incidence of reciprocal translocation (2.4 %) was higher than that of Robertsonian translocation (1.0 %).
This study suggests that type of translocations should be emphasized in genetic counseling and in evaluation of recurrent spontaneous abortion.
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